* PubMed link to all manuscripts with Christian Mosimann
* PubMed link to all manuscripts with Alexa Burger
* bioRxiv link to all our preprints
Past and present lab members marked in bold.
2022
Next-generation plasmids for transgenesis in zebrafish and beyond
Kemmler KL, Moran HR, Murray BF, Scoresby A, Klem JR, Eckert EL, Lepovsky E, Bertho S, Nieuwenhuize S, Burger S, D'Agati G, Betz C, Puller A, Felker A, Ditrychova K, Boetschi S, Affolter M, Rohner N, Lovely CB, Kwan KM*, Burger A*, Mosimann C*.
bioRxiv 2022.12.13.520107; doi: https://doi.org/10.1101/2022.12.13.520107
Preprint, including vector sequences and maps
Molecular Function and Contribution of TBX4 in Development and Disease.
Karolak JA, Welch CL, Mosimann C, Bzdega K, West JD, Montani D, Eyries M, Mullen MP, Abman SH, Prapa M, Gräf S, Morrell NW, Hemnes AR, Perros F, Hamid R, Logan MPO, Whitsett J, Galambos C, Stankiewicz P, Chung WK, Austin ED; TBX4Life Initiative.
Am J Respir Crit Care Med. 2022 Nov 11. doi: 10.1164/rccm.202206-1039TR. Online ahead of print.
PMID: 36367783
The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Mansour F, Hinze C, Telugu NS, Kresoja J, Shaheed IB, Mosimann C, Diecke S, Schmidt-Ott KM.
Elife. 2022 Oct 12;11:e80165. doi: 10.7554/eLife.80165. Online ahead of print.
PMID: 36222666
Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2.
Mattonet K, Riemslagh FW, Guenther S, Prummel KD, Kesavan G, Hans S, Ebersberger I, Brand M, Burger A, Reischauer S, Mosimann C, Stainier DYR.
Sci Adv. 2022 Sep 2;8(35):eabn2082. doi: 10.1126/sciadv.abn2082. Epub 2022 Aug 31.
PMID: 36044573
Heterogeneity and genomic loci of ubiquitous transgenic Cre reporter lines in zebrafish
Lalonde RL, Kemmler CL, Riemslagh FW, Aman AJ, Kresoja-Rakic J, Moran HR, Nieuwenhuize S, Parichy DM, Burger A*, Mosimann C*.
*co-corresponding authors
Dev Dyn. 2022 May 18. doi: 10.1002/dvdy.499. Online ahead of print.
PMID: 35582941
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Prummel KD, Crowell HL, Nieuwenhuize S, Brombacher EC, Daetwyler S, Soneson C, Kresoja-Rakic J, Kocere A, Ronner M, Ernst A, Labbaf Z, Clouthier DE, Firulli AB, Sánchez-Iranzo H, Naganathan SR, O'Rourke R, Raz E, Mercader N, Burger A, Felley-Bosco E, Huisken J, Robinson MD, Mosimann C.
Nat Commun. 2022 Mar 30;13(1):1677. doi: 10.1038/s41467-022-29311-7.
PMID: 35354817
Multisite Gateway Calculations: Excel Spreadsheet
Mosimann C
protocols.io. 2022, Feb 11. doi: 10.17504/protocols.io.b4xdqxi6.
PMID: 35354817
2021
Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis.
Ulloa BA, Habbsa SS, Potts KS, Lewis A, McKinstry M, Payne SG, Flores JC, Nizhnik A, Feliz Norberto M, Mosimann C, Bowman
TV.
Cell Rep. 2021 Sep 14;36(11):109703. doi: 10.1016/j.celrep.2021.109703.
PMID: 34525360
Persistent Ventricle Partitioning in the Adult Zebrafish Heart.
Pfefferli C*, Moran HR*, Felker A, Mosimann C1, Jaźwińska A1.
* equal contribution, 1 co-corresponding authors
J Cardiovasc Dev Dis. 2021 Apr 9;8(4):41. doi: 10.3390/jcdd8040041.
PMID: 33918756
From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.
Kemmler CL*, Riemslagh FW*, Moran HR*, Mosimann C.
* equal contribution
J Cardiovasc Dev Dis. 2021 Feb 10;8(2):17. doi: 10.3390/jcdd8020017.
PMID: 33578943
2020
Development at a Glance: The lateral plate mesoderm
Prummel KD*, Nieuwenhuize S*, Mosimann C.
* equal contribution
Development 2020 147: dev175059 doi: 10.1242/dev.175059; open access, 19 June 2020.
PMID: 32561665
2019
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates.
Prummel KD*, Hess C*, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Czarkwiani A, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C.
* equal contribution
Nat Commun. 2019 Aug 26;10(1):3857. doi: 10.1038/s41467-019-11561-7.
PMID: 31451684
Anterior trunk muscle shows mix of axial and appendicular developmental patterns.
Sagarin KA, Redgrave AC, Mosimann C, Burke AC, Devoto SH.
Dev Dyn. 2019 Oct;248(10):961-968. doi: 10.1002/dvdy.95. Epub 2019 Aug 16.
PMID: 31386244
Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
D‘Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A.
Dis Model Mech. 2019 Jun 20. pii: dmm.039545. doi: 10.1242/dmm.039545. [Epub ahead of print].
PMID: 31221659
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms.
Brunner E, Yagi R, Debrunner M, Beck-Schneider D, Burger A, Escher E, Mosimann C, Hausmann G, Basler K.
Life Sci Alliance. 2019 Jun 13;2(3). pii: e201800267. doi: 10.26508/lsa.201800267. Print 2019 Jun.
PMID: 31196871
A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates.
Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, Krumlauf R.
Nat Commun. 2019 Mar 13;10(1):1189. doi: 10.1038/s41467-019-09197-8.
PMID: 30867425
2018
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling
Cantù C*, Felker A*, Zimmerli D*, Prummel KD, Cabello EM, Chiavacci E, Méndez-Acevedo KM, Kirchgeorg L, Burger S, Ripoll J, Valenta T, Hausmann G, Vilain N, Aguet M, Burger A, Panáková D, Basler K1, Mosimann C1.
*equal contribution; 1 co-corresponding authors
Genes Dev. 2018 Nov 1;32(21-22):1443-1458. doi: 10.1101/gad.315531.118. Epub 2018 Oct 26.
PMID: 30366904
Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish.
Kirchgeorg L*, Felker A*, van Oostrom M, Chiavacci E, Mosimann C.
* equal contribution
Dev Dyn. 2018 Sep 8. doi: 10.1002/dvdy.24668. [Epub ahead of print]
PMID: 30194800
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ).
Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM.
Dis Model Mech. 2018 Jul 30. pii: dmm.034561. doi: 10.1242/dmm.034561. [Epub ahead of print].
PMID: 30061297
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
Merks AM, Swinarski M, Meyer AM, Müller NV, Özcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S & Panáková D.
Nat Commun. 2018 Jun 4;9(1):2161. doi: 10.1038/s41467-018-04566-1.
PMID: 29867082.
Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Panáková D*, Mosimann C*.
* co-corresponding authors
Nat Commun. 2018 May 21;9(1):2001. doi: 10.1038/s41467-018-04402-6.
PMID: 29784942
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzinghi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasagni L, Romagnani P.
Nat Commun. 2018 Apr 9;9(1):1344. doi: 10.1038/s41467-018-03753-4.
PMID: 29632300
Switch and Trace: Recombinase Genetics in Zebrafish.
Carney TJ*, Mosimann C*.
* co-corresponding authors
Trends Genet. 2018 Feb 8. pii: S0168-9525(18)30004-0. doi: 10.1016/j.tig.2018.01.004. [Epub ahead of print] Review.
PMID: 29429760
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.
Sánchez-Iranzo H, Galardi-Castilla M, Minguillón C, Sanz-Morejón A, González-Rosa JM, Felker A, Ernst A, Guzmán-Martínez G, Mosimann C, Mercader N.
Nat Commun. 2018 Jan 30;9(1):428. doi: 10.1038/s41467-017-02650-6.
PMID: 29382818
2017
Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF.
Elife. 2017 Nov 9;6. pii: e22626. doi: 10.7554/eLife.22626.
PMID: 29117894
Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes.
Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G.
Sci Rep. 2017 Aug 30;7(1):10061. doi: 10.1038/s41598-017-10347-5.
PMID: 28855635
A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish.
D'Agati G, Beltre R, Sessa A, Burger A, Zhou Y, Mosimann C*, White RM*.
*co-corresponding authors
Dev Biol. 2017 Jul 28. pii: S0012-1606(17)30373-1. doi: 10.1016/j.ydbio.2017.07.017. [Epub ahead of print]
PMID: 28760346
CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus.
Heinze SD, Kohlbrenner T, Ippolito D, Meccariello A, Burger A, Mosimann C, Saccone G, Bopp D.
Sci Rep. 2017 Jul 4;7(1):4582. doi: 10.1038/s41598-017-04686-6.
PMID: 28676649
Early frameshift alleles of zebrafish tbx5a that fail to develop the heartstrings phenotype
Chiavacci E, Kirchgeorg L, Felker A, Burger A, Mosimann C.
Science Matters. 2017 Apr 11. doi: 10.19185/matters.201703000011
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.
Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CVH.
Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231.
PMID: 28387645
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.
Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L.
Nat Cell Biol. 2017 Jan;19(1):17-27. doi: 10.1038/ncb3444. Epub 2016 Nov 21.
PMID: 27870830
An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates.
Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, Santoro MM.
Development. 2017 Feb 1;144(3):464-478. doi: 10.1242/dev.133926. Epub 2017 Jan 3.
PMID: 28049660
2016
Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.
Felker A, Mosimann C.
Methods Cell Biol. 2016;135:219-44. doi: 10.1016/bs.mcb.2016.01.009.
PMID: 27443928
CrispRVariants charts the mutation spectrum of genome engineering experiments.
Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C*, Robinson MD*.
*co-corresponding authors
Nat Biotechnol. 2016 Jul 12;34(7):701-2. doi: 10.1038/nbt.3628.
PMID: 27404876
Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.
Burger A*, Lindsay H*, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C.
*equal contribution
Development. 2016 Jun 1;143(11):2025-37. doi: 10.1242/dev.134809.
PMID:27130213
In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control.
Felker A*, Nieuwenhuize S*, Dolbois A, Blazkova K, Hess C, Low LW, Burger S, Samson N, Carney TJ, Bartunek P, Nevado C, Mosimann C.
*equal contribution
PLoS One. 2016 Apr 14;11(4):e0152989. doi: 10.1371/journal.pone.0152989. eCollection 2016.
PMID:27077909
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.
Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI.
Science. 2016 Jan 29;351(6272):aad2197. doi: 10.1126/science.aad2197. Epub 2016 Jan 28.
PMID:26823433
2015
Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators.
Musso G, Mosimann C, Panáková D, Burger A, Zhou Y, Zon LI, MacRae CA.
Genom Data. 2015 Sep 16;6:199-201. doi: 10.1016/j.gdata.2015.09.015. eCollection 2015 Dec.
PMID:26697374
Chamber identity programs drive early functional partitioning of the heart.
Mosimann C*, Panáková D*, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI.
*equal contribution
Nat Commun. 2015 Aug 26;6:8146. doi: 10.1038/ncomms9146.
PMID: 26306682
Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced.
Lasagni L, Angelotti ML, Ronconi E, Lombardi D, Nardi S, Peired A, Becherucci F, Mazzinghi B, Sisti A, Romoli S, Burger A, Schaefer B, Buccoliero A, Lazzeri E, Romagnani P.
Stem Cell Reports. 2015 Aug 11;5(2):248-63. doi: 10.1016/j.stemcr.2015.07.003. Epub 2015 Jul 30.
PMID: 26235895
Wnt/ß-catenin signaling is required for radial glial neurogenesis following spinal cord injury.
Briona LK, Poulain FE, Mosimann C, Dorsky RI.
Dev Biol. 2015 Jul 1;403(1):15-21. doi: 10.1016/j.ydbio.2015.03.025. Epub 2015 Apr 14.
PMID:25888075
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.
Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espín-Palazón R, Lawson ND, Dorsky R, Clements WK, Traver D.
Development. 2015 Mar 15;142(6):1050-61. doi: 10.1242/dev.119180.
PMID:25758220
2014
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.
Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA, Haber DA.
Dis Model Mech. 2014 Jul;7(7):907-13. doi: 10.1242/dmm.013128. Epub 2013 Dec 5.
PMID: 24311731
Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.
Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA.
Development. 2014 Jan;141(1):224-35. doi: 10.1242/dev.099796.
PMID:24346703
2013
A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis.
Paik EJ, Mahony S, White RM, Price EN, Dibiase A, Dorjsuren B, Mosimann C, Davidson AJ, Gifford D, Zon LI.
Stem Cell Reports. 2013 Nov 7;1(5):425-36. doi: 10.1016/j.stemcr.2013.10.001. eCollection 2013.
PMID:24286030
Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system.
Mosimann C*, Puller AC*, Lawson KL, Tschopp P, Amsterdam A, Zon LI.
*equal contribution
Dev Dyn. 2013 Aug;242(8):949-63. doi: 10.1002/dvdy.23989. Epub 2013 Jul 3.
PMID:23723152
2011
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.
Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI.
Cell. 2011 Oct 28;147(3):577-89. doi: 10.1016/j.cell.2011.09.044.
PMID:22036566
Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.
Mosimann C, Zon LI.
Methods Cell Biol. 2011;104:173-94. doi: 10.1016/B978-0-12-374814-0.00010-0.
PMID:21924163
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish.
Zhou Y, Cashman TJ, Nevis KR, Obregon P, Carney SA, Liu Y, Gu A, Mosimann C, Sondalle S, Peterson RE, Heideman W, Burns CE, Burns CG.
Nature. 2011 May 29;474(7353):645-8. doi: 10.1038/nature10094.
PMID: 21623370
Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish.
Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI.
Development. 2011 Jan;138(1):169-77. doi: 10.1242/dev.059345.
PMID:21138979
2009
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster.
Goetze S*, Qeli E*, Mosimann C*, Staes A*, Gerrits B, Roschitzki B, Mohanty S, Niederer EM, Laczko E, Timmerman E, Lange V, Hafen E, Aebersold R, Vandekerckhove J, Basler K, Ahrens CH, Gevaert K, Brunner E.
*equal contribution
PLoS Biol. 2009 Nov;7(11):e1000236. doi: 10.1371/journal.pbio.1000236. Epub 2009 Nov 3.
PMID: 19885390
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.
Mosimann C, Hausmann G, Basler K.
Mech Dev. 2009 May-Jun;126(5-6):394-405. doi: 10.1016/j.mod.2009.02.002. Epub 2009 Feb 11.
PMID: 19368795
Beta-catenin hits chromatin: regulation of Wnt target gene activation.
Mosimann C, Hausmann G, Basler K.
Nat Rev Mol Cell Biol. 2009 Apr;10(4):276-86. doi: 10.1038/nrm2654. Review.
PMID: 19305417
2006
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Mosimann C*, Hausmann G*, Basler K.
*equal contribution
Cell. 2006 Apr 21;125(2):327-41.
PMID: 16630820
* PubMed link to all manuscripts with Alexa Burger
* bioRxiv link to all our preprints
Past and present lab members marked in bold.
2022
Next-generation plasmids for transgenesis in zebrafish and beyond
Kemmler KL, Moran HR, Murray BF, Scoresby A, Klem JR, Eckert EL, Lepovsky E, Bertho S, Nieuwenhuize S, Burger S, D'Agati G, Betz C, Puller A, Felker A, Ditrychova K, Boetschi S, Affolter M, Rohner N, Lovely CB, Kwan KM*, Burger A*, Mosimann C*.
bioRxiv 2022.12.13.520107; doi: https://doi.org/10.1101/2022.12.13.520107
Preprint, including vector sequences and maps
Molecular Function and Contribution of TBX4 in Development and Disease.
Karolak JA, Welch CL, Mosimann C, Bzdega K, West JD, Montani D, Eyries M, Mullen MP, Abman SH, Prapa M, Gräf S, Morrell NW, Hemnes AR, Perros F, Hamid R, Logan MPO, Whitsett J, Galambos C, Stankiewicz P, Chung WK, Austin ED; TBX4Life Initiative.
Am J Respir Crit Care Med. 2022 Nov 11. doi: 10.1164/rccm.202206-1039TR. Online ahead of print.
PMID: 36367783
The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Mansour F, Hinze C, Telugu NS, Kresoja J, Shaheed IB, Mosimann C, Diecke S, Schmidt-Ott KM.
Elife. 2022 Oct 12;11:e80165. doi: 10.7554/eLife.80165. Online ahead of print.
PMID: 36222666
Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2.
Mattonet K, Riemslagh FW, Guenther S, Prummel KD, Kesavan G, Hans S, Ebersberger I, Brand M, Burger A, Reischauer S, Mosimann C, Stainier DYR.
Sci Adv. 2022 Sep 2;8(35):eabn2082. doi: 10.1126/sciadv.abn2082. Epub 2022 Aug 31.
PMID: 36044573
Heterogeneity and genomic loci of ubiquitous transgenic Cre reporter lines in zebrafish
Lalonde RL, Kemmler CL, Riemslagh FW, Aman AJ, Kresoja-Rakic J, Moran HR, Nieuwenhuize S, Parichy DM, Burger A*, Mosimann C*.
*co-corresponding authors
Dev Dyn. 2022 May 18. doi: 10.1002/dvdy.499. Online ahead of print.
PMID: 35582941
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Prummel KD, Crowell HL, Nieuwenhuize S, Brombacher EC, Daetwyler S, Soneson C, Kresoja-Rakic J, Kocere A, Ronner M, Ernst A, Labbaf Z, Clouthier DE, Firulli AB, Sánchez-Iranzo H, Naganathan SR, O'Rourke R, Raz E, Mercader N, Burger A, Felley-Bosco E, Huisken J, Robinson MD, Mosimann C.
Nat Commun. 2022 Mar 30;13(1):1677. doi: 10.1038/s41467-022-29311-7.
PMID: 35354817
Multisite Gateway Calculations: Excel Spreadsheet
Mosimann C
protocols.io. 2022, Feb 11. doi: 10.17504/protocols.io.b4xdqxi6.
PMID: 35354817
2021
Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis.
Ulloa BA, Habbsa SS, Potts KS, Lewis A, McKinstry M, Payne SG, Flores JC, Nizhnik A, Feliz Norberto M, Mosimann C, Bowman
TV.
Cell Rep. 2021 Sep 14;36(11):109703. doi: 10.1016/j.celrep.2021.109703.
PMID: 34525360
Persistent Ventricle Partitioning in the Adult Zebrafish Heart.
Pfefferli C*, Moran HR*, Felker A, Mosimann C1, Jaźwińska A1.
* equal contribution, 1 co-corresponding authors
J Cardiovasc Dev Dis. 2021 Apr 9;8(4):41. doi: 10.3390/jcdd8040041.
PMID: 33918756
From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.
Kemmler CL*, Riemslagh FW*, Moran HR*, Mosimann C.
* equal contribution
J Cardiovasc Dev Dis. 2021 Feb 10;8(2):17. doi: 10.3390/jcdd8020017.
PMID: 33578943
2020
Development at a Glance: The lateral plate mesoderm
Prummel KD*, Nieuwenhuize S*, Mosimann C.
* equal contribution
Development 2020 147: dev175059 doi: 10.1242/dev.175059; open access, 19 June 2020.
PMID: 32561665
2019
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates.
Prummel KD*, Hess C*, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Czarkwiani A, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C.
* equal contribution
Nat Commun. 2019 Aug 26;10(1):3857. doi: 10.1038/s41467-019-11561-7.
PMID: 31451684
Anterior trunk muscle shows mix of axial and appendicular developmental patterns.
Sagarin KA, Redgrave AC, Mosimann C, Burke AC, Devoto SH.
Dev Dyn. 2019 Oct;248(10):961-968. doi: 10.1002/dvdy.95. Epub 2019 Aug 16.
PMID: 31386244
Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
D‘Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A.
Dis Model Mech. 2019 Jun 20. pii: dmm.039545. doi: 10.1242/dmm.039545. [Epub ahead of print].
PMID: 31221659
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms.
Brunner E, Yagi R, Debrunner M, Beck-Schneider D, Burger A, Escher E, Mosimann C, Hausmann G, Basler K.
Life Sci Alliance. 2019 Jun 13;2(3). pii: e201800267. doi: 10.26508/lsa.201800267. Print 2019 Jun.
PMID: 31196871
A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates.
Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, Krumlauf R.
Nat Commun. 2019 Mar 13;10(1):1189. doi: 10.1038/s41467-019-09197-8.
PMID: 30867425
2018
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling
Cantù C*, Felker A*, Zimmerli D*, Prummel KD, Cabello EM, Chiavacci E, Méndez-Acevedo KM, Kirchgeorg L, Burger S, Ripoll J, Valenta T, Hausmann G, Vilain N, Aguet M, Burger A, Panáková D, Basler K1, Mosimann C1.
*equal contribution; 1 co-corresponding authors
Genes Dev. 2018 Nov 1;32(21-22):1443-1458. doi: 10.1101/gad.315531.118. Epub 2018 Oct 26.
PMID: 30366904
Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish.
Kirchgeorg L*, Felker A*, van Oostrom M, Chiavacci E, Mosimann C.
* equal contribution
Dev Dyn. 2018 Sep 8. doi: 10.1002/dvdy.24668. [Epub ahead of print]
PMID: 30194800
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ).
Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM.
Dis Model Mech. 2018 Jul 30. pii: dmm.034561. doi: 10.1242/dmm.034561. [Epub ahead of print].
PMID: 30061297
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
Merks AM, Swinarski M, Meyer AM, Müller NV, Özcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S & Panáková D.
Nat Commun. 2018 Jun 4;9(1):2161. doi: 10.1038/s41467-018-04566-1.
PMID: 29867082.
Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Panáková D*, Mosimann C*.
* co-corresponding authors
Nat Commun. 2018 May 21;9(1):2001. doi: 10.1038/s41467-018-04402-6.
PMID: 29784942
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzinghi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasagni L, Romagnani P.
Nat Commun. 2018 Apr 9;9(1):1344. doi: 10.1038/s41467-018-03753-4.
PMID: 29632300
Switch and Trace: Recombinase Genetics in Zebrafish.
Carney TJ*, Mosimann C*.
* co-corresponding authors
Trends Genet. 2018 Feb 8. pii: S0168-9525(18)30004-0. doi: 10.1016/j.tig.2018.01.004. [Epub ahead of print] Review.
PMID: 29429760
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.
Sánchez-Iranzo H, Galardi-Castilla M, Minguillón C, Sanz-Morejón A, González-Rosa JM, Felker A, Ernst A, Guzmán-Martínez G, Mosimann C, Mercader N.
Nat Commun. 2018 Jan 30;9(1):428. doi: 10.1038/s41467-017-02650-6.
PMID: 29382818
2017
Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF.
Elife. 2017 Nov 9;6. pii: e22626. doi: 10.7554/eLife.22626.
PMID: 29117894
Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes.
Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G.
Sci Rep. 2017 Aug 30;7(1):10061. doi: 10.1038/s41598-017-10347-5.
PMID: 28855635
A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish.
D'Agati G, Beltre R, Sessa A, Burger A, Zhou Y, Mosimann C*, White RM*.
*co-corresponding authors
Dev Biol. 2017 Jul 28. pii: S0012-1606(17)30373-1. doi: 10.1016/j.ydbio.2017.07.017. [Epub ahead of print]
PMID: 28760346
CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus.
Heinze SD, Kohlbrenner T, Ippolito D, Meccariello A, Burger A, Mosimann C, Saccone G, Bopp D.
Sci Rep. 2017 Jul 4;7(1):4582. doi: 10.1038/s41598-017-04686-6.
PMID: 28676649
Early frameshift alleles of zebrafish tbx5a that fail to develop the heartstrings phenotype
Chiavacci E, Kirchgeorg L, Felker A, Burger A, Mosimann C.
Science Matters. 2017 Apr 11. doi: 10.19185/matters.201703000011
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.
Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CVH.
Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231.
PMID: 28387645
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.
Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L.
Nat Cell Biol. 2017 Jan;19(1):17-27. doi: 10.1038/ncb3444. Epub 2016 Nov 21.
PMID: 27870830
An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates.
Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, Santoro MM.
Development. 2017 Feb 1;144(3):464-478. doi: 10.1242/dev.133926. Epub 2017 Jan 3.
PMID: 28049660
2016
Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.
Felker A, Mosimann C.
Methods Cell Biol. 2016;135:219-44. doi: 10.1016/bs.mcb.2016.01.009.
PMID: 27443928
CrispRVariants charts the mutation spectrum of genome engineering experiments.
Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C*, Robinson MD*.
*co-corresponding authors
Nat Biotechnol. 2016 Jul 12;34(7):701-2. doi: 10.1038/nbt.3628.
PMID: 27404876
Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.
Burger A*, Lindsay H*, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C.
*equal contribution
Development. 2016 Jun 1;143(11):2025-37. doi: 10.1242/dev.134809.
PMID:27130213
In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control.
Felker A*, Nieuwenhuize S*, Dolbois A, Blazkova K, Hess C, Low LW, Burger S, Samson N, Carney TJ, Bartunek P, Nevado C, Mosimann C.
*equal contribution
PLoS One. 2016 Apr 14;11(4):e0152989. doi: 10.1371/journal.pone.0152989. eCollection 2016.
PMID:27077909
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.
Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI.
Science. 2016 Jan 29;351(6272):aad2197. doi: 10.1126/science.aad2197. Epub 2016 Jan 28.
PMID:26823433
2015
Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators.
Musso G, Mosimann C, Panáková D, Burger A, Zhou Y, Zon LI, MacRae CA.
Genom Data. 2015 Sep 16;6:199-201. doi: 10.1016/j.gdata.2015.09.015. eCollection 2015 Dec.
PMID:26697374
Chamber identity programs drive early functional partitioning of the heart.
Mosimann C*, Panáková D*, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI.
*equal contribution
Nat Commun. 2015 Aug 26;6:8146. doi: 10.1038/ncomms9146.
PMID: 26306682
Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced.
Lasagni L, Angelotti ML, Ronconi E, Lombardi D, Nardi S, Peired A, Becherucci F, Mazzinghi B, Sisti A, Romoli S, Burger A, Schaefer B, Buccoliero A, Lazzeri E, Romagnani P.
Stem Cell Reports. 2015 Aug 11;5(2):248-63. doi: 10.1016/j.stemcr.2015.07.003. Epub 2015 Jul 30.
PMID: 26235895
Wnt/ß-catenin signaling is required for radial glial neurogenesis following spinal cord injury.
Briona LK, Poulain FE, Mosimann C, Dorsky RI.
Dev Biol. 2015 Jul 1;403(1):15-21. doi: 10.1016/j.ydbio.2015.03.025. Epub 2015 Apr 14.
PMID:25888075
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.
Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espín-Palazón R, Lawson ND, Dorsky R, Clements WK, Traver D.
Development. 2015 Mar 15;142(6):1050-61. doi: 10.1242/dev.119180.
PMID:25758220
2014
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.
Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA, Haber DA.
Dis Model Mech. 2014 Jul;7(7):907-13. doi: 10.1242/dmm.013128. Epub 2013 Dec 5.
PMID: 24311731
Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.
Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA.
Development. 2014 Jan;141(1):224-35. doi: 10.1242/dev.099796.
PMID:24346703
2013
A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis.
Paik EJ, Mahony S, White RM, Price EN, Dibiase A, Dorjsuren B, Mosimann C, Davidson AJ, Gifford D, Zon LI.
Stem Cell Reports. 2013 Nov 7;1(5):425-36. doi: 10.1016/j.stemcr.2013.10.001. eCollection 2013.
PMID:24286030
Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system.
Mosimann C*, Puller AC*, Lawson KL, Tschopp P, Amsterdam A, Zon LI.
*equal contribution
Dev Dyn. 2013 Aug;242(8):949-63. doi: 10.1002/dvdy.23989. Epub 2013 Jul 3.
PMID:23723152
2011
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.
Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI.
Cell. 2011 Oct 28;147(3):577-89. doi: 10.1016/j.cell.2011.09.044.
PMID:22036566
Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments.
Mosimann C, Zon LI.
Methods Cell Biol. 2011;104:173-94. doi: 10.1016/B978-0-12-374814-0.00010-0.
PMID:21924163
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish.
Zhou Y, Cashman TJ, Nevis KR, Obregon P, Carney SA, Liu Y, Gu A, Mosimann C, Sondalle S, Peterson RE, Heideman W, Burns CE, Burns CG.
Nature. 2011 May 29;474(7353):645-8. doi: 10.1038/nature10094.
PMID: 21623370
Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish.
Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI.
Development. 2011 Jan;138(1):169-77. doi: 10.1242/dev.059345.
PMID:21138979
2009
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster.
Goetze S*, Qeli E*, Mosimann C*, Staes A*, Gerrits B, Roschitzki B, Mohanty S, Niederer EM, Laczko E, Timmerman E, Lange V, Hafen E, Aebersold R, Vandekerckhove J, Basler K, Ahrens CH, Gevaert K, Brunner E.
*equal contribution
PLoS Biol. 2009 Nov;7(11):e1000236. doi: 10.1371/journal.pbio.1000236. Epub 2009 Nov 3.
PMID: 19885390
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.
Mosimann C, Hausmann G, Basler K.
Mech Dev. 2009 May-Jun;126(5-6):394-405. doi: 10.1016/j.mod.2009.02.002. Epub 2009 Feb 11.
PMID: 19368795
Beta-catenin hits chromatin: regulation of Wnt target gene activation.
Mosimann C, Hausmann G, Basler K.
Nat Rev Mol Cell Biol. 2009 Apr;10(4):276-86. doi: 10.1038/nrm2654. Review.
PMID: 19305417
2006
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Mosimann C*, Hausmann G*, Basler K.
*equal contribution
Cell. 2006 Apr 21;125(2):327-41.
PMID: 16630820